Beilstein J. Org. Chem.2016,12, 343–348, doi:10.3762/bjoc.12.37
of a dipeptidephosphine catalyst, a wide range of highly functionalized cyclopentenes bearing an all-carbon quaternary center were obtained in moderate to good yields and with good to excellent enantioselectivities.
Keywords: [3 + 2] annulation; α-substituted allenoate; dipeptidephosphine
reaction was improved to 68%. To further improve the reaction results, we next utilized dipeptidephosphine catalysts, which are more structurally diverse and tunable. The L-thr-L-thr-derived catalyst 4a was a poor catalyst, on the other hand, L-val-L-thr-derived catalyst 4b led to adequately improved
PDF
Graphical Abstract
Scheme 1:
The [3 + 2] annulation of α-substituted allenoates reported by He.